Although there are some larger cup-sized characters on this list, none of them are too ridiculously over-proportioned. Those "anime exclusives" I am not a "big" fan of.
Lust, from Fullmetal Alchemist, is open, deadly (capable), assertive, confident, and yet in the first series oddly motherly toward Wrath and Gluttony. She uses her bust as a weapon to distract males time to time…just before skewering them. Bleach’s Rukia is one of the small breasted characters.
Although anime guys go after the buxom bosom, the small chested girl usually gets the happy ending. Big bosoms are just more common since they appeal to a wide audience right now. It is a matter of time before culture swings back in preference to the small bust.