Darker than Black: Kuro no Keiyakusha has a blind girl, Yin, in the main cast.
A popular youtuber named Millbeeful did a complete read-through and had to fight to keep his youtube account because of half a second of anime boobs that he forgot to censor. Still one of the most hilarious playthroughs in existence. 3. Continue this thread.
Toph Bei Fong is ...TECHNICALLY blind, the hand wave explaining it was well done though.
It's definitely a school-based romantic drama, but there is also H2O: Footprints In The Sand.
Not an anime, but I highly recommend the visual novel Katawa Shoujo, if you've never played a VN before, this is the perfect one to start you off.